The Tiflis uezd was a county (uezd) of the Tiflis Governorate of the Caucasus Viceroyalty of the Russian Empire, and then of Democratic Republic of Georgia, with its administrative centre in Tiflis. The area of the uezd roughly corresponded to the contemporary Kvemo Kartli region of Georgia. The district bordered the Telavi uezd to the northeast, the Tionety and Dusheti uezds to the north, the Gori uezd to the northwest, the Borchaly uezd to the west, the Kazakh uezd of the Elizavetpol Governorate to the south, and the Signakh uezd to the east.